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Do Not Coadminister

Elvitegravir/Cobicistat/ Emtricitabine/Tenofovir alafenamide (EVG/c/FTC/TAF)

Simvastatin

Quality of Evidence: Very Low

Summary:

Coadministration is contraindicated as it is expected to markedly increase simvastatin concentrations which may cause myopathy, including rhabdomyolysis.

Description:

Co-administration is contraindicated due to the potential for serious or life-threatening adverse reactions, such as myopathy, including rhabdomyolysis.
Genvoya Summary of Product Characteristics, Gilead Sciences International Ltd, November 2021.

Coadministration is contraindicated due to potential for increased simvastatin concentrations and serious reactions such as myopathy, including rhabdomyolysis.
Genvoya US Prescribing Information, Gilead Sciences Inc, September 2021.

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