Interaction Checker

Cookies help us deliver our services. By using our services, you agree to our use of cookies. Learn more

Prescribing Resources

We have produced a series of materials in PDF format to aid prescribing.

Treatment Selectors show interactions between key antiretrovirals and drugs used to treat a range of common comorbidities.

Prescribing and Dosing Guidance give advice and recommendations for the use of HIV drugs in specific patient populations.

Interactions Explained describe the pharmacology of different mechanisms of interaction that may occur with HIV therapy.

Interaction Summary Tables provide an overview of interactions between HIV drugs and the comedications listed in the interaction checker.

Pharmacokinetic Fact Sheets contain information on the pharmacokinetics, metabolism and disposition of HIV drugs and have been collated from product labels and published literature on licensed doses (unless otherwise stated).

Please click on the headings below to see the full range of resources within each section.

Treatment Selectors (by therapeutic indication)

Analgesics

Updated November 2024

Anticoagulants & Antiplatelets

Updated November 2024

Antidepressants

Updated November 2024

Anti-Hypertensives

Updated November 2024

Anti-Malarials

Updated November 2024

Antipsychotics

Updated November 2024

Anti-Tuberculosis Therapies

Updated November 2024

Anxiolytics & Hypnotics

Updated November 2024

Beta Blockers

Updated November 2024

Bronchodilators for COPD

Updated November 2024

Calcium Channel Blockers

Updated November 2024

Cancer Therapies

Updated November 2024

Contraceptives

Updated November 2024

Corticosteroids

Updated November 2024

Diabetes Therapies

Updated November 2024

Gender Affirmation Therapies

Updated November 2024

Herbal and Mineral Supplements

Updated November 2024

Hormone Replacement Therapy (HRT)

Updated November 2024

Immunosuppressants for SOT

Updated November 2024

Lipid Lowering

Updated November 2024

Pulmonary Anti-hypertensives

Updated November 2024

ARVs and Recreational Drugs

Updated November 2024

Prescribing and Dosing Guidance

Drug-drug interactions with moderate intensity statins

Updated November 2024

Interactions with lenacapavir

Updated October 2024

Interactions with hormone therapy for gender affirmation

Updated October 2024

ARVs for patients with swallowing difficulties

Updated October 2024

ARVs and food requirements

Updated October 2024

Dosing of ARVs for patients with renal impairment

Updated October 2024

Interactions with FTC/TDF PrEP and long-term use medications

Updated October 2024

Use of apixaban with strong CYP3A4 and P-gp inhibitors

Updated March 2024

ARV absorption and gastric surgery

Updated October 2023

Interaction potential of chemsex drugs

Updated October 2022

Prescribing guidance for elderly PLWH

Updated October 2022

Guidance for the use of non-oral steroids and strong CYP3A4 inhibitors

Updated October 2022

Dosing of selected non-ARVs for patients with renal impairment

Updated October 2022

Considerations and interactions when switching from ritonavir-boosted to cobicistat-boosted atazanavir or darunavir

Updated October 2022

Interactions Explained

Interactions with herbal and mineral supplements

Updated November 2024

Enzyme induction by flucloxacillin

Updated April 2024

Dose dependent enzyme induction

Updated December 2022

Interactions following oral, intramuscular or subcutaneous administration

Updated October 2022

Interactions with integrase inhibitors and cations in antacids and supplements/vitamins

Updated October 2022

Interaction Summary Tables

Interactions with Protease Inhibitors

Updated November 2024

Interactions with NNRTIs

Updated November 2024

Interactions with NRTIs

Updated November 2024

Interactions with Integrase Inhibitors

Updated November 2024

Interactions with Entry, Attachment and Capsid Inhibitors

Updated November 2024

Interactions between key ARVs

Updated November 2024

Pharmacokinetic Fact Sheets

Abacavir (ABC)

Updated March 2016

Albuvirtide

Updated October 2022

Atazanavir

Updated March 2016

Bictegravir

Updated October 2018

Cabotegravir (IM)

Updated February 2021

Cabotegravir (oral)

Updated February 2021

Cobicistat

Updated March 2016

Dapivirine (vaginal ring)

Updated July 2021

Darunavir

Updated October 2018

Dolutegravir

Updated March 2016

Doravirine

Updated March 2023

Efavirenz

Updated March 2016

Elvitegravir

Updated March 2016

Emtricitabine (FTC)

Updated March 2016

Etravirine

Updated March 2016

Fostemsavir

Updated July 2021

Lamivudine (3TC)

Updated March 2016

Lenacapavir

Updated October 2022

Lopinavir

Updated March 2016

Maraviroc

Updated March 2016

Nevirapine

Updated March 2016

Raltegravir

Updated March 2016

Rilpivirine (IM)

Updated February 2021

Rilpivirine (oral)

Updated February 2021

Ritonavir

Updated March 2016

Tenofovir alafenamide (TAF)

Updated January 2024

Tenofovir-DF (TDF)

Updated March 2016

Zidovudine

Updated March 2016

Drug Interactions with 3HP for TB

Drug interaction summary tables and interaction notes for weekly isoniazid/rifapentine (3HP)

Updated October 2021
SPONSORS
EDITORIAL SPONSORS
Awards and commendations
bma-foundation-for-medical-research british-medical-journal-2018 queens_aniversary_prize_2017 rcp-excellence-patient-care-awards-2017
healthline-best-HIV-and-AIDS-apps-of-2019
building_better_healthcare_awards_2016 healthline-best-HIV-and-AIDS-apps-of-2016