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Do Not Coadminister

Elvitegravir/Cobicistat/ Emtricitabine/Tenofovir alafenamide (EVG/c/FTC/TAF)

Ergotamine

Quality of Evidence: Very Low

Summary:

Coadministration is contraindicated due to potential for serious and/or life threatening events such as acute ergot toxicity characterized by peripheral vasospasm and ischemia of the extremities and other tissues.

Description:

Co-administration is contraindicated due to the potential for serious or life-threatening adverse reactions, such as peripheral vasospasm or ischaemia.
Genvoya Summary of Product Characteristics, Gilead Sciences International Ltd, November 2021.

Coadministration is contraindicated due to potential for increased concentrations of ergotamine and serious and/or life-threatening events such as acute ergot toxicity characterized by peripheral vasospasm and ischemia of the extremities and other tissues.
Genvoya US Prescribing Information, Gilead Sciences Inc, September 2021.

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