Coadministration has not been studied but based on the metabolism and clearance a clinically significant interaction is unlikely. Lormetazepam is mainly glucuronidated. Rilpivirine, emtricitabine and tenofovir alafenamide do not interact with this metabolic pathway. 

Coadministration has not been studied but based on metabolism and clearance a clinically significant interaction is unlikely. Varenicline is eliminated unchanged by the kidneys via glomerular filtration and active tubular secretion by OCT2. Rilpivirine, tenofovir alafenamide and emtricitabine are unlikely to significantly interact with varenicline.