Etravirine and fluconazole can be used without dose adjustments. Coadministration of fluconazole (200 mg once daily in the morning) and etravirine decreased fluconazole AUC, Cmin and Cmax by 6%, 9%, and 8%, respectively. Etravirine AUC, Cmin and Cmax increased by 1.86-, 2.09- and 1.75-fold, respectively.
Intelence Summary of Product Characteristics, Janssen-Cilag Ltd, March 2019.

Coadministration of etravirine and fluconazole (200 mg once daily) was studied in 16 subjects. Etravirine Cmax, AUC and Cmin increased by 75%, 86% and 2.09-fold, respectively. Fluconazole Cmax, AUC and Cmin decreased by 8%, 6% and 9%, respectively. Co-administration of etravirine and fluconazole significantly increased etravirine exposures. The amount of safety data at these increased etravirine exposures is limited, therefore, etravirine and fluconazole should be coadministered with caution. No dose adjustment of etravirine or fluconazole is needed.
Intelence US Prescribing Information, Janssen Therapeutics, July 2019. The pharmacokinetic interaction between etravirine (200 mg twice daily) and fluconazole (200 mg once daily) was studied in HIV- subjects. Etravirine AUC, Cmax and Cmin by increased 86%, 75% and 2.09-fold, respectively (n=16). Fluconazole AUC, Cmax and Cmin decreased by 6%, 8% and 9%, respectively (n=15). Combinations were generally safe and well tolerated.
Pharmacokinetic interaction between etravirine and fluconazole or voriconazole in HIV-negative volunteers. Scholler-Gyure M, Kakuda TN, van Solingen-Ristea R, et al. 49th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, September 2009, abstract A1-1299.