Interaction Checker
Do Not Coadminister
Darunavir + ritonavir (DRV/r)
Triamcinolone
Quality of Evidence: Low
Summary:
Coadministration is not recommended unless the potential benefit of treatment outweighs the risk of systemic corticosteroid effects. Triamcinolone is metabolised by CYP3A4 and coadministration with boosted PIs could increase concentrations of triamcinolone. There are several case reports of Cushing's syndrome with the use of intra articular triamcinolone injections in patients on boosted PIs. A reduced dose of methylprednisolone has been suggested as a possible safer alternative to triamcinolone injection although there is insufficient information to indicate whether other injectable steroids present a lower risk than triamcinolone.
Description:
No Version Present
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