Coadministration has not been studied. Clorazepate is rapidly converted to nordiazepam which is then metabolized to oxazepam by CYP3A4. Darunavir/cobicistat could potentially increase nordiazepam exposure which could prolong sedation. Clinical and/or concentration monitoring is recommended and a dosage reduction may be required. Emtricitabine and tenofovir alafenamide do not interact with this metabolic pathway.