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Potential Interaction

Darunavir/cobicistat (DRV/c)

Alprazolam

Quality of Evidence: Very Low

Summary:

Coadministration has not been studied. Alprazolam is mainly metabolized by CYP3A4. Coadministration of darunavir/cobicistat may increase alprazolam concentrations and may result in enhanced sedation. A decrease in alprazolam dose may be needed.

Description:

(See Summary)

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