Coadministration has not been studied. Coadministration of ciclosporin, a potent P-gp inhibitor, is expected to increase plasma concentrations of tenofovir alafenamide. The recommended dose of Descovy is 200/10 mg once daily (where available). Of note: ciclosporin can impair renal function but this is unlikely to be problematic as tenofovir alafenamide results in 90% lower systemic levels of tenofovir compared to tenofovir-DF.