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Potential Interaction

Tenofovir-DF (TDF)

Clarithromycin

Quality of Evidence: Very Low

Summary:

Coadministration has not been studied. A clinically significant effect on clarithromycin is unlikely as it is mainly metabolized by CYP3A4. However, tenofovir-DF (the prodrug of tenofovir) is a substrate of P-gp and inhibitors of P-gp such as clarithromycin could potentially increase the absorption of tenofovir-DF, thereby increasing the systemic concentration of tenofovir. Monitoring of tenofovir-associated adverse reactions, including frequent renal monitoring, is recommended.

Description:

(See Summary)

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