Liverpool HIV Interactions

Interaction Checker

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No Interaction Expected

Doravirine/Lamivudine/ Tenofovir-DF (DOR/3TC/TDF)

Methadone

Quality of Evidence: Very Low

Summary:

Coadministration with doravirine, lamivudine and tenofovir-DF has not been studied. Coadministration of multiple doses of doravirine to subjects on stable oral methadone maintenance therapy (20-180 mg once daily) did not have a clinically meaningful effect on both methadone and doravirine pharmacokinetics. Coadministration of tenofovir-DF or lamivudine were shown to have no clinically significant effects on methadone pharmacokinetics in subjects on stable methadone maintenance therapy.

Description:

Coadministration of methadone (20-200 mg once daily, individualized dose) and doravirine (100 mg once daily) decreased doravirine AUC, Cmax and C24 by 26%, 24% and 20%, respectively. R-methadone AUC, Cmax and C24 decreased by 5%, 2% and 5%, respectively; S-methadone AUC, Cmax and C24 decreased by 2%, 3% and 3%, respectively. No dose adjustment is required.

Delstrigo Summary of Product Characteristics, Merck Sharp & Dohme Ltd, November 2018.

No clinically significant change in drug concentrations were observed when methadone was co-administered with doravirine. No clinically significant drug interactions have been observed between TDF and methadone in studies with healthy subjects.

Delstrigo US Prescribing Information, Merck & Co Inc, August 2018.

Co-administration of doravirine (100 mg, once daily) and methadone (20-200 mg, once daily, dependant on treatment plan) in 14 subjects. Dose adjusted R-methadone AUC, C24 and Cmax were reduced by 5%, 5%, and 2%, respectively. Doravirine AUC, C24, Cmax decreased 26%, 20% and 24% respectively. The authors conclude there was no clinically relevant drug interaction.

A study to evaluate the pharmacokinetic interaction between doravirine and methadone. Khalilieh SM Yee KL, Sanchez R, et al. 16th European AIDS Conference, Milan, October 2017, abstract: PE210/14.

View all available interactions with Doravirine/Lamivudine/ Tenofovir-DF (DOR/3TC/TDF) by clicking here.