Liverpool HIV Interactions

Interaction Checker

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No Interaction Expected

Doravirine/Lamivudine/ Tenofovir-DF (DOR/3TC/TDF)

Antacids

Quality of Evidence: Very Low

Summary:

Coadministration with Delstrigo has not been studied but based on metabolism and clearance a clinically significant interaction is unlikely. Coadministration of doravirine and antacids containing aluminium hydroxide (1600 mg), magnesium hydroxide (1600 mg) and simethicone (160 mg) did not significantly alter doravirine pharmacokinetics. Similarly, antacids are unlikely to impact lamivudine and tenofovir-DF pharmacokinetics.

Description:

Coadministration of an antacid containing aluminium and magnesium hydroxide (20 ml single dose) and doravirine (100 mg single dose) increased doravirine AUC and C24 by 1% and 3%, but decreased Cmax by 14%. No dose adjustment is required.

Delstrigo Summary of Product Characteristics, Merck Sharp & Dohme Ltd, November 2018.

No clinically significant change in doravirine concentration was observed when doravirine was coadministered with an aluminum hydroxide/magnesium hydroxide/simethicone containing antacid.

Delstrigo US Prescribing Information, Merck & Co Inc, August 2018.

Co-administration of doravirine (100 mg single dose) was studied with a single dose of an antacid suspension (1600 mg each aluminum hydroxide and magnesium hydroxide, and 160 mg of simethicone) was studied in 13 subjects. Doravirine Cmax decreased by 14% and AUC and C24 increased by 1% and 3%, respectively. The authors conclude co-administration did not have a clinically relevant effect of doravirine pharmacokinetics.

Co-administration of doravirine with an aluminum/magnesium containing antacid or pantoprazole, a proton pump inhibitor, does not have a clinically meaningful effect on doravirine pharmacokinetics. Khalilieh S, Yee KL, Sanchez RI, et al. 9th IAS Conference on HIV Science, Paris July 2017, abstract MOPEB0334.

View all available interactions with Doravirine/Lamivudine/ Tenofovir-DF (DOR/3TC/TDF) by clicking here.