Co-administration of pantoprazole (40 mg once daily) and doravirine (100 mg single dose) decreased doravirine AUC, Cmax and C24 by 17%, 12% and 16%, respectively. No dose adjustment is required.

No clinically significant change in doravirine concentration was observed when pantoprazole was co-administered with doravirine.

Co-administration of doravirine (100 mg single dose) and pantoprazole sodium (40 mg once daily, slow release tablet) was studied in 13 subjects. Doravirine Cmax, AUC, and C24 decreased by 12%, 17% and 16%, respectively. The authors conclude co-administration did not have a clinically relevant effect of doravirine pharmacokinetics.