When taken with food, Triumeq and supplements or multivitamins containing calcium, iron or magnesium can be taken at the same time. If Triumeq is taken in a fasted state, such supplements should be taken a minimum 2 hours after or 6 hours before the intake of Triumeq. Coadministration of multivitamins (containing calcium, iron and magnesium) and dolutegravir decreased dolutegravir AUC, Cmax and C24 by 33%, 35% and 32%, respectively. The stated reductions in dolutegravir exposure were observed with the intake of dolutegravir and these supplements during fasted conditions. In fed state, the changes in exposure following intake together with calcium or iron supplements were modified by the food effect, resulting in an exposure similar to that obtained with dolutegravir administered in the fasted state.

Coadministration may decrease dolutegravir concentrations. Coadministration of a multivitamin preparation (One-A-Day, single dose) and dolutegravir (50 mg, single dose) was studied in 16 subjects. Dolutegravir Cmax, AUC and Ctrough decreased by 35%, 33% and 32%, respectively. Administer Triumeq 2 hours before or 6 hours after taking medications containing polyvalent cations.

Coadministration of a multivitamin preparation with high metal divalent cation content (One-A-Day, single dose) and dolutegravir (50 mg, single dose) was studied in 16 HIV-negative subjects and was found to decrease dolutegravir AUC, Cmax and Ctrough by 33%, 35% and 32%, respectively.