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Do Not Coadminister

Rilpivirine/ Emtricitabine/Tenofovir-DF (RPV/FTC/TDF)

Bictegravir/ Emtricitabine/Tenofovir alafenamide (BIC/FTC/TAF)

Quality of Evidence: Very Low

Summary:

Biktarvy (bictegravir, emtricitabine, tenofovir alafenamide) and Eviplera/Complera (rilpivirine, emtricitabine, tenofovir-DF) are indicated for use as complete regimens for the treatment of HIV-1 infection and should not be administered with other antiretroviral products. Furthermore, Biktarvy contains tenofovir alafenamide and emtricitabine and should not be administered with tenofovir-DF or additional emtricitabine (both components of Eviplera/Complera).

Description:

Eviplera should not be administered concomitantly with other medicinal products containing emtricitabine or with tenofovir alafenamide.
Eviplera Summary of Product Information, Gilead Sciences Ltd, August 2021.

Because Complera is a complete regimen, coadministration with other antiretroviral medications for the treatment of HIV-1 infection is not recommended.
Complera US Prescribing Information, Gilead Sciences Inc, November 2019.

Biktarvy should not be co-administered with other antiretroviral medicinal products.
Biktarvy Summary of Product Characteristics, Gilead Sciences Ltd, June 2019.

As Biktarvy is a complete regimen, coadministration with other antiretroviral medications for the treatment of HIV-1 infection is not recommended.
Biktarvy Prescribing Information, Gilead Sciences Inc, August 2019.

View all available interactions with Rilpivirine/ Emtricitabine/Tenofovir-DF (RPV/FTC/TDF) by clicking here.

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