The combination of Juluca and H2-receptor antagonists should be used with particular caution. Only H2-receptor antagonists that can be dosed once daily should be used. H2-receptor antagonists should be taken well separated in time from the administration of Juluca (minimum 4 hours after or 12 hours before). Juluca should not be co-administered at the same time as H2-receptor antagonists. Coadministration with dolutegravir has not been studied but no effect on dolutegravir pharmacokinetics is expected. Coadministration with rilpivirine has not been studied but significant decreases in rilpivirine plasma concentrations are expected (reduced absorption due to gastric pH increase).

Coadministration is expected to have no effect on dolutegravir concentrations but to decrease rilpivirine concentrations. Juluca should only be administered at least 4 hours before or 12 hours after taking H2-receptor antagonists.