LHPG Comment: Unlike the Videx chewable/dispersible tablets,the new formulation of ddI (Videx EC) does not contain antacids. Interactions with the old formulation that were due to the presence of antacid should not apply to the new formulation. Timing of administration of Videx EC with other medications will still be dependent on food requirements, but no longer on gastric pH requirements.

Kaletra TABLETS can be administered simultaneously with didanosine without food. For Kaletra ORAL SOLUTION, it is recommended that didanosine be administered on an empty stomach. Therefore, didanosine should be given one hour before or two hours after Kaletra oral solution (which is taken with food).
Kaletra Prescribing Information, AbbVie Ltd, October 2020.