Interaction Checker
Potential Interaction
Lopinavir/ritonavir (LPV/r)
Trazodone
Quality of Evidence: Moderate
Summary:
Coadministration of ritonavir (200 mg twice daily) and a single dose of trazodone increased trazodone AUC by 2.4-fold. Adverse events of nausea, dizziness, hypotension and syncope were observed. The effect on trazodone exposure of a lower dose of ritonavir (100 mg twice daily) in combination with lopinavir is unknown. The combination should be used with caution and a lower dose of trazodone should be considered. Note, both drugs have risks of QT prolongation and/or TdP on the CredibleMeds.org website (possible risk for lopinavir; conditional risk for trazodone). If coadministration is necessary, clinical monitoring including ECG assessment is recommended.
Description:
Coadministration of low dose ritonavir (200 mg twice daily) with a single dose of trazodone led to an increase in plasma concentrations of trazodone (AUC increased by 2.4 fold). Adverse events of nausea, dizziness, hypotension and syncope were observed following co-administration of trazodone and ritonavir. It is unknown whether the combination of lopinavir/ritonavir cause a similar increase in trazodone exposure. The combination should be used with caution and a lower dose of trazodone should be considered.
Kaletra Summary of Product Characteristics, AbbVie Ltd, January 2021.
Concomitant use of trazodone and lopinavir may increase trazodone concentrations. Adverse reactions of nausea, dizziness, hypotension and syncope have been observed following co-administration of trazodone and ritonavir.
Kaletra Prescribing Information, AbbVie Ltd, October 2020.
View all available interactions with Lopinavir/ritonavir (LPV/r) by clicking here.
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