Interaction Checker
Potential Interaction
Tenofovir-DF (TDF)
Sulfadiazine
Quality of Evidence: Very Low
Summary:
Coadministration has not been studied. Sulfadiazine has been associated with crystalluria leading to renal toxicity and in some cases renal failure, and case reports in immunocompromised patients have suggested that AIDS patients may be particularly prone to sulfadiazine-induced renal toxicity. Use of tenofovir-DF should be avoided with concurrent or recent use of a nephrotoxic medicinal product. If coadministration is unavoidable, renal function should be monitored closely.
Description:
Tenofovir disoproxil fumarate has not been evaluated in patients receiving nephrotoxic medicinal products (e.g. aminoglycosides, amphotericin B, foscarnet, ganciclovir, pentamidine, vancomycin, cidofovir or interleukin-2). Use of tenofovir disoproxil fumarate should be avoided with concurrent or recent use of a nephrotoxic medicinal product. If concomitant use of tenofovir disoproxil fumarate and nephrotoxic agents is unavoidable, renal function should be monitored weekly.
Viread Summary of Product Characteristics, Gilead Sciences Ltd, September 2016.
Tenofovir-DF should be avoided with concurrent or recent use of a nephrotoxic agent. Since tenofovir-DF is primarily eliminated by the kidneys, coadministration of tenofovir-DF with drugs that reduce renal function or compete for active tubular secretion may increase serum concentrations of tenofovir and/or increase the concentrations of other renally eliminated drugs. Some examples include, but are not limited to, cidofovir, acyclovir, valacyclovir, ganciclovir, valganciclovir, aminoglycosides (e.g., gentamicin), and high-dose or multiple NSAIDs.
Viread Prescribing Information, Gilead Sciences International Inc, February 2016.
View all available interactions with Tenofovir-DF (TDF) by clicking here.
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