Liverpool HIV Interactions

Stribild is indicated for use as a complete regimen for the treatment of HIV 1 infection and must not be administered with other antiretroviral products.
Stribild Summary of Product Characteristics, Gilead Sciences International Ltd, November 2021.

Stribild is a complete regimen for the treatment of HIV-1 infection; therefore, Stribild should not be administered with other antiretroviral medications for treatment of HIV-1 infection.

Stribild Prescribing Information, Gilead Sciences Inc, September 2021.

Healthy volunteers received ritonavir over a 20 to 200 mg dose range once daily with elvitegravir (125 mg once daily). Plasma exposures of elvitegravir increased with increasing doses of ritonavir. Relative to 20 mg ritonavir dose, elvitegravir apparent oral clearance was significantly decreased by 38%, 52% and 52% for 50, 100 and 200 mg doses of ritonavir, respectively.

Dose-response of ritonavir on hepatic CYP3A activity and elvitegravir oral exposure. Mathias AA, West S, Hui J, Kearney BP. Clin Pharmacol Ther, 2009, 85(1): 64-70.