Coadministration has not been studied. Orlistat should only be used with emtricitabine/tenofovir alafenamide if separated by 4-5 hours. Orlistat reduces dietary fat absorption and may affect the absorption of antiretrovirals (especially if lipophilic). [Note: this interaction is not specific for emtricitabine/tenofovir alafenamide, but for any medication taken with orlistat.]