Coadministration has not been studied but based on metabolism and clearance, a clinically significant interaction is unlikely. Isoniazid is acetylated in the liver to form acetylisoniazid which is then hydrolysed to isonicotinic acid and acetylhydrazine. Bictegravir, emtricitabine and tenofovir alafenamide do not interfere with isoniazid’s metabolic pathway.