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No Interaction Expected

Darunavir/cobicistat (DRV/c)

Pantoprazole

Quality of Evidence: Very Low

Summary:

Coadministration has not been studied but based on metabolism and clearance a clinically significant interaction is unlikely as pantoprazole is unlikely to alter darunavir/cobicistat absorption.

Description:

Based on theoretical considerations, no mechanistic interaction is expected. Darunavir/cobicistat can be co-administered with proton pump inhibitors without dose adjustments.
Rezolsta Summary of Product Characteristics, Janssen-Cilag Ltd, July 2023.

Clinically relevant drug-drug interactions are not anticipated with concomitant use of darunavir and cobicistat with proton pump inhibitors.
Prezcobix US Prescribing Information, Janssen Pharmaceuticals Inc, March 2023.

View all available interactions with Darunavir/cobicistat (DRV/c) by clicking here.

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