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Do Not Coadminister

Darunavir/Cobicistat/ Emtricitabine/Tenofovir alafenamide (DRV/c/FTC/TAF)

Ergotamine

Quality of Evidence: Very Low

Summary:

Coadministration with ergotamine and is contraindicated due to potential for serious and/or life threatening events such as acute ergot toxicity characterized by peripheral vasospasm and ischemia of the extremities and other tissues. Ergotamine is metabolized by CYP3A4.

Description:

Coadministration is contraindicated due to the potential for serious and/or life threatening adverse reactions. Based on theoretical considerations darunavir/cobicistat may increase ergotamine exposure.
Symtuza Summary of Product Characteristics, Janssen-Cilag Ltd, June 2023.

Co-administration is contraindicated due to potential for serious and/or life-threatening reactions such as acute ergot toxicity characterized by peripheral vasospasm and ischemia of the extremities and other tissues. Co-administration is expected to increase ergotamine concentrations.
Symtuza US Prescribing Information, Janssen Products, March 2023.

View all available interactions with Darunavir/Cobicistat/ Emtricitabine/Tenofovir alafenamide (DRV/c/FTC/TAF) by clicking here.

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