Coadministration has not been studied. Paliperidone is primarily eliminated renally (possibly via OCT), with minimal metabolism occurring via CYP2D6 and CYP3A4. Darunavir/cobicistat could potentially increase paliperidone, although to a limited extent and no a priori dosage adjustment is needed. Emtricitabine and tenofovir derived from tenofovir alafenamide are unlikely to significantly impair paliperidone elimination.