Coadministration with dolutegravir/rilpivirine has not been studied. Coadministration of omeprazole (40 mg once daily) and dolutegravir (50 mg single dose) decreased dolutegravir Cmax, AUC and Ctrough by 8%, 3% and 5%, respectively. Coadministration is contraindicated due to the potential for significant decreases in rilpivirine plasma concentrations due to gastric pH increase, which may result in loss of virologic response. When rilpivirine (150 mg once daily) and omeprazole (20 mg once daily) were coadministered, rilpivirine exposure decreased by ~40% and omeprazole exposure decreased by ~14%. [Note: this interaction study has been performed with a dose higher than the licensed dose for rilpivirine assessing the maximal effect on the co-administered drug. The recommendation is applicable to the licensed dose of rilpivirine 25 mg once daily.]