The past two months have seen the addition of 19 new comedications to the interaction checker and the removal of one (artemisinin). The new comedications are listed below.
- Aficamten (Hypertension / Heart Failure Agents)
- Arformoterol (Bronchodilators)
- Artemether (Antiprotozoals)
- Artesunate (Antiprotozoals)
- Calcifediol (Calcidiol) (Herbals/Supplements/Vitamins)
- Calcitriol (Other)
- Elinzanetant (Other)
- Eluxadoline (Gastrointestinal Agents)
- Gepotidacin (Antibacterials)
- Ibrexafungerp (Antifungals)
- Lofexidine (Other)
- Mavacamten (Hypertension / Heart Failure Agents)
- Milsaperidone (Antipsychotics/Neuroleptics)
- Naloxegol (Gastrointestinal Agents)
- Pimavanserin (Antipsychotics/Neuroleptics)
- Samidorphan (Other)
- Suvorexant (Anxiolytics/Hypnotics/ Sedatives)
- Vorapaxar (Anti-coagulant, Anti-platelet and Fibrinolytic)
- Zavegepant (Antimigraine Agents)
A few interaction colour changes have also been made in response to updated information and/or for consistency.
- Benzonatate now has a conditional risk of TdP on the Credible Medicines website and interactions with efavirenz, fostemsavir and rilpivirine (and rilpivirine-containing combinations) have been changed from green to yellow. A comment about the updated risk status has been added to interactions for atazanavir (alone and with ritonavir or cobicistat) and lopinavir, but no colour change was required.
- The interaction between ursodeoxycholic acid and lenacapavir has been changed from red to amber for consistency with some of the other ARVs.
