Interaction Checker

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New Prescribing Resource – enzyme induction by flucloxacillin

Tuesday 13 June 2023

A new prescribing resource giving details of the enzyme induction observed with flucloxacillin has been added to the “Interactions Explained” section of the Prescribing Resources page.

Flucloxacillin is an antibiotic which has been shown to induce CYP3A4 in vitro. Several publications have reported clinical evidence of it reducing trough concentrations of tacrolimus, posaconazole and voriconazole. However, awareness of the inducing potential of flucloxacillin is low as it has not yet been incorporated into most international drug interaction checkers nor in product labels.

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